ICAN BioCollection
The Biological Resource Center (BRC) ICAN BioCollection
The CRB ICAN BioCollection (formerly named Bio ICAN) integrates activities of collection/reception, sample processing (centrifugation, aliquoting, DNA and RNA extraction, …), storage at -20°C, -80°C and -150°C with temperature monitoring and provision of biological resources. Several types of biological samples are stored in ICAN BioCollection: serum, plasma, buffy coat, adipose tissue (subcutaneous, mesenteric, omental), liver tissue, urine, stool, saliva… New sample treatments can be set up at the user’s request.
Team
The CRB team is made up of its manager Sara CIPRIANI, PhD, as well as the technical team, with Jean-Baptiste BLOND, Ludivine HARMAND, and Houdah ALI KASSIM. The quality manager of the CRB is Sarah MATIGNON, quality engineer.
The governance of the CRB is ensured by an Executive Committee (COMEX)
L’organigramme du CRB est consultable ici : CRB ICAN BioCollection Organization Chart
Certificate
The CRB ICAN BioCollection obtained the double certification ISO 9001 : 2015 and NF S 96-900 : 2011 in December 2019 for the reception, preparation, conservation, provision of biological resources of human origin relating to cardiometabolic diseases and the hosting of biological samples. This certification was granted by the Euro-quality system certification body in November 2019. This is the result of a quality approach initiated many years ago and testifies to the willingness of CRB ICAN BioCollection to continuously improve the quality of its services in order to guarantee the satisfaction of its stakeholders.
Benefits
Direct debit management
- Preparation of sampling kits
- Receipt of direct debits
- Sample management: serum, plasma, PBMC, circulating and cellular DNA and RNA extraction, urine
- Stool aliquoting
- Non-invasive labeling of samples (use of QR-code tube)
- Inventory
Storage of biological samples
- Storage temperature variable according to needs: – 20°C, – 80°C, -150°C
- Temperature tracking report
- Collection duplication (two levels of separation between two freezers; separation between two storage sites)
- Storage capacity: 1 million samples
- 24/7 temperature monitoring; on-call weekends and public holidays
Return of biological samples
- Preparation of samples for shipment
- Transport organization
Support for these services is provided by the expertise of Sara CIPRIANI. In addition, the IHU ICAN offers many other services with its technical platforms, clinical platform, etc. You can see them here .
Political quality
The quality policy is a requirement of the NF S96-900:2011 and ISO 9001: 2015 standard. It presents the orientations in terms of quality given by the management in connection with the strategy of the IHU ICAN. It is the reference allowing to direct the quality approach.
La politique Qualité est consultable ici : Quality Policy – CRB ICAN BioCollection
Quality Manual
Our Quality Manual is a document describing the Quality Management System (QMS) of our CRB. It defines the organization of our structure meeting the scope of the dual certification NF S96-900 and ISO 9001, describes the processes and establishes the list of our procedures.
Terms of cooperation
Within the framework of its collaborations, the BRC has drafted a Charter which aims to govern the relationship between ICAN BioCollection and its Interested Parties in accordance with the ethical principles governing the collection of elements and products of the human body as well as their derivatives, and with the legislative and regulatory provisions governing the activity of collection, processing and storage of the said products, as well as the information associated with them.
In order to optimize the use of the Collections and the samples currently deposited and to be deposited in the future, ICAN BioCollection has drafted this policy, the terms of which will be binding on all persons accessing ICAN BioCollection services.
La Charte Bio-ICAN est consultable ici : Charte CRB ICAN BioCollection
Reproduction and use without permission prohibited.
Support for these services is provided by the expertise of Sara CIPRIANI. In addition, the IHU ICAN offers many other services with its technical platforms, clinical platform, etc. You can see them here .
Legal authorization
- The bank declared its activity to the Ministry in charge of Research under the number DC – 2013 – 1971, dated 26/07/2014
- The bank has declared compliance with MR004 (2204190 v 0).
Key figures
26
Scientific cohorts
24
Phase II and III clinical studies
1500+
Direct debits received each year
7000+
Samples prepared each year
6000+
Samples made available each year
Collectible catalog
In this table you will find the available biological sample collections.
If you are interested in our Biological Resources, or for the establishment of a collection of Biological Resources within the CRB, you can contact the CRB by CRB.Bio-ICAN@ihuican.org or fill out our request forms below.
collection
Approach
pathology
Acute Coronary Syndrome
sample(s)
Serum, plasma, DNA, urine, stool
Responsible
Prof. Johanne SILVAIN
started in
2015
Summary
Acute Coronary Syndrome (ACS) is the obstruction of one or more coronary arteries. The objective of this study is to better understand the etiology and pathophysiology of acute coronary syndrome. The APPROACH collection was created in 2015 by Pr. Johanne SILVAIN PU-PH within the Cardiology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum, plasma, urine, stool and DNA samples with numerous associated clinical data.
collection
Myocardium
pathology
Heart failure / cardiomyopathy
sample(s)
Serum, plasma, DNA, urine, stool
Responsible
Prof. Richard ISNARD
started in
2015
Summary
The purpose of this study is to monitor patients suffering from heart failure syndrome or cardiomyopathy (CMD). The syndrome is heterogeneous and one of the objectives of this project is to highlight or validate new diagnostic and prognostic biomarkers. The MYOCARD collection was created in 2015 by Pr. Philippe Charron PU-PH within the Cardiology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum, plasma, urine, stool and DNA samples with numerous associated clinical data.
collection
iPS-CARDIOGEN
pathology
Hereditary Heart Diseases (cardiomyopathies/electrical diseases)/hereditary vascular diseases
sample(s)
Serum, DNA, PBMC, Skin fibroblasts
Responsible
Prof. Philippe CHARRON
started in
2015
Summary
The mechanisms related to human hereditary heart or vascular diseases remain largely unknown. The objective of the iPS-CARDIOGEN study is to develop new experimental models to study hereditary heart and vascular diseases. The iPS-CARDIOGEN collection was created in 2015 by Pr. Philippe Charron, PU-PH within the Reference Center for Cardiac Diseases of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum and DNA samples with numerous associated clinical data. Link to relevant study:
http://www.cardiogen.aphp.fr/upload/presentation_ips_cardiogen.pdf
collection
FIFA/EPOS/LITMUS
pathology
Metabolic steatosis of the liver
sample(s)
Blood, plasma, urine, liver biopsy
Responsible
Prof. Vlad RATZIU
started in
2015
Summary
Metabolic fatty liver is a chronic liver disease associated with the presence of one or more metabolic risk factors or sleep apnea syndrome, in the absence of another cause of chronic liver disease. Metabolic steatosis can progress to liver fibrosis and cirrhosis. The main research axes of the study related to the collection are the understanding of the physiopathology of metabolic steatosis of the liver and the development of diagnostic tools. The FIFA-EPOS collection was created in 2015 by Pr. Vlad Ratziu, PU-PH in the Hepato-gastro-enterology department of the Pitié Salpêtrière – Charles Foix University Hospitals, and consists of serum and DNA samples with numerous associated clinical data. Link to relevant study:
http://www.epos-nafld.eu/
https://cordis.europa.eu/project/rcn/193284/factsheet/en
https://litmus-project.eu/
https://cordis.europa.eu/project/id/777377/fr
collection
Anode
pathology
Diabetes type 2 / Obesity
sample(s)
Plasma
Responsible
dr. Boris Hansel
started in
2014
Summary
Type 2 diabetes is a disease characterized by chronic hyperglycemia, which usually develops in adults and more so in obese or overweight people. The aim of the ANODE study was to test online coaching to improve eating habits and physical abilities in type 2 diabetic patients through a bicentric randomized trial. The ANODE collection was created in 2014 by Dr. Boris Hansel, MCU-PH in the Department of Diabetology – Endocrinology and Nutrition at Bichat-Claude Bernard Hospital, and consists of serum samples with numerous associated clinical data.
collection
FH-CALC
pathology
Heterozygous autosomal dominant familial hypercholesterolemia
sample(s)
Serum, Plasma, stool
Responsible
dr. Antonio Gallo
started in
2018
Summary
Familial hypercholesterolemia is an inherited metabolic disorder characterized by elevated LDL cholesterol in the blood. The main lines of research of the FH-CALC study are the understanding of the pathophysiology of familial hypercholesterolemia and the development of diagnostic tools. The FH-CALC collection was created in 2018 by Dr. Antonio Gallo, Associate Practitioner, Internist at the Cardiovascular Disease Prevention Unit of the Cardiology and Metabolism Center of the Pitié Salpêtrière – Charles Foix University Hospitals and is made up of serum, plasma and stool samples. Numerous clinical data are associated with the samples.
collection
CORO NASH
pathology
Metabolic fatty liver/cardiovascular disease
sample(s)
DNA, serum, stool, liver biopsy
Responsible
dr. Raluca Pais
started in
2018
Summary
The relationship between metabolic fatty liver disease (NAFLD), metabolic steatohepatitis of the liver (NASH) and atherosclerotic coronary artery disease (MC-ATS) is now recognized due to common cardiometabolic risk factors (FRMs), the likely role of NAFLD/NASH in the occurrence of pre-atherosclerotic lesions and myocardial dysfunction associated with NAFLD/NASH. The aim of this study is to determine the prevalence of NAFLD/NASH in patients admitted to cardiology with suspected coronary disease. The CORO-NASH collection was created in 2019 by Dr. Raluca Pais within the Hepato-Gastroenterology Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of DNA, serum, stool, liver biopsy samples with numerous associated clinical data.
collection
Obeco
pathology
Obesity
sample(s)
Serum
Responsible
Prof. Anne Bachelot
started in
2018
Summary
The effectiveness of oral contraceptives depends on blood levels of these drugs after digestive absorption and their distribution in the body. Surgeries for obesity with malabsorption (gastric bypass) can in theory alter the biological availability of drugs in obese patients. The aim of this study is to evaluate the pharmacokinetics of oral contraceptives in obese women before and after bariatric surgery. The OBECO collection was created in 2015 by Pr. Anne Bachelot, Pu-PH in the Endocrinology and Reproductive Medicine Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and is made up of serum samples with numerous clinical data associated with the samples.
collection
CARDIO-MET
pathology
Familial hypercholesterolemia
sample(s)
Serum, plasma
Responsible
Professor Eric BRUCKERT
started in
2021
Summary
The crucial role of dyslipidemia, particularly hypercholesterolemia, in the development of cardiovascular disease is particularly well documented. Familial hypercholesterolemia (FH) is a genetic disease characterized by elevated plasma concentrations of LDLC. Lipoproteins rich in triglycerides (TRL), contribute to the progression of cardiovascular diseases. The aim of this study is to compare the apolipoproteic profile of patients with HF by comparing those with associated hyperTG with those with isolated hypercholesterolemia. The CARDIO-MET collection was created in 2021 by Pr Eric BRUCKERT within the Endocrinology and Metabolism Department of the Pitié Salpêtrière – Charles Foix University Hospitals, and consists of serum and plasma samples with associated clinical data.
collection
IMPULSMACS
pathology
Heart failure
sample(s)
Serum, DNA, circulating RNA, PBMC
Responsible
Dr Guillaume Lebreton
started in
2021
Summary
The implantation of LVAD (Left Ventricular Assist Device) constitutes a medium to long-term therapeutic option for patients with end-stage heart failure with isolated left ventricular dysfunction. However, their use remains limited by the frequency of their side effects, which are mostly unpredictable. Several factors, including pulsatility, have been associated with LVAD complications in the literature, including bleeding complications. However, the pathophysiological pathways associated with decreased pulsatility are poorly understood. The prospective follow-up of the patients included in this study aims to study the pathophysiological pathways associated with the reduction in pulsatility and leading to complications of LVAD. The IMPULSMACS collection was created in 2021 by Dr Guillaume Lebreton in the Cardiac Surgery Department of the Pitié Salpêtrière University Hospitals – Charles Foix, and consists of samples of serum, DNA, circulating RNA, PBMC with associated clinical data. Link to relevant study: https://clinicaltrials.gov/ct2/show/NCT04951999
Pricing of services
benefits
ICAN/SU (€/unit)
Academic (excluding SU) & Industrial
Receipt of sample tubes
Reception
7 €
CRI grid
Freezing (without technicage)
Tube
€1
CRI grid
Technicage
Preparation serum/plasma 2D tube
€2.30
CRI grid
Serum/plasma preparation 2ml tube
€2.30
CRI grid
Stool aliquoting
€2.50
CRI grid
Tissue preparation for inclusion
€2.50
CRI grid
DNA extraction from blood
33 €
CRI grid
RNA extraction from soft tissue (except adipose tissue)
35 €
CRI grid
Plasma/serum RNA extraction
28 €
CRI grid
Size adipocytes
18 €
CRI grid
Technician HR time excluding technicage (€/h)
28 €
CRI grid
Step freezing
8 €
CRI grid
PBMC Preparation
30 €
CRI grid
Cell count and viability
7 €
CRI grid
Freezing viable cells
9 €
CRI grid
Storage
2D tube -80°C
€0.05
CRI grid
Tube 2ml -80°C
€0.08
CRI grid
Tube 5ml -80°C
€0.34
CRI grid
Tube 12ml-15ml -80°C
€0.60
CRI grid
Tube 2ml – 150°C
€1.05
CRI grid
Destocking
Tube
€1
CRI grid
Click here to consult the national price list for CRBs and certified hospital tumor banks established by the Research and Innovation Commission (CRI) of the Conference of General Managers of CHU.
Contact(s)
Building E3M – 6th floor
47-48 hospital bd
75013 Paris ICAN
You wish…
Processing of your personal data: The processing complies with the provisions of the CNIL (law relating to data processing, files and freedoms as well as the general regulations on data protection). To exercise your rights regarding the processing of your personal data: mesdonnees@ican-institute.org