State-of-the-art technologies such as mass spectrometry coupled with gas or liquid chromatography allow us to guarantee quantitative and ultra-sensitive analyzes on hundreds of lipid species in various biological matrices.

Expertise and services

1. Complex profiling by LC-ESI-MS/MS

  • Glycerophospholipids (238): PC, LPC, PE, LPE, plasmalogen PE, PI, PG, LPG, BMP, PS, PA
  • Sphingolipids (70): Sphingomyelin (SM), ceramides, dihydroceramide (DHC), acylceramides
  • Neutral lipids (135): TAG, DAG, MAG, CE, cholesterol

2. Targeted approach for studies of specific metabolic pathways (LC-MS/MS and GC-EI/CI-MS)

  • Metabolites from the microbiota: stanols (coprostanol, epicoprostanol, ethylcoprostanol), bile acids (primary, secondary, conjugated)
  • Free fatty acids (FFA) (27 lipids): 15:0, 16:0, 16:1, 17:0, 18:0, 18:1, 18:2, 18:3 (w3 and w6), 20: 0, 20:1, 20:2, 20:3 (w3 and w6), 20:4, 20:5, 22:0, 22:1, 22:4, 22:6, 23:0, 24:0 , 24:1
  • Cholesterol synthesis pathway: squalene, lanosterol, desmosterol, lathosterol, cholesterol
  • Intestinal absorption markers: phytosterols (campesterol, β-sitosterol, stigmasterol), cholestanol

Matrices: Biofluids (plasma, serum, lipoproteins (VLDL, LDL HDL)), faeces, tissue (liver, adipose tissue, brain, heart, muscle), others (exosomes, mitochondria, cells, bacteria, etc.)

Equipment on the platform

  • GC-MS: Trace 1310/ISQ LT (ThermoFisherScientific)
  • LC-MS/MS: HPLC (Prominence Shimadzu)/ QTrap 4000 (AB Sciex)
  • Pre-analytical automaton LV200 (Biotage)
  • Precellys Evolution homogenizer (Ozyme),
  • Positive pressure manifold (Waters positive pressure manifold – 96)
  • SPD131DDA speed vacuum concentrator with cryogenic trap (Thermo Fisher Scientific).

Current developments

  • Sphingosines, sphingosine-1-Phosphate
  • Oxysterols

Lipidomics Platform Interaction Radiation

  • Education: reference platform for the OMICS course of the Biomics master’s degree from Université Paris Est Créteil
    Local networks: UMS RésOmique SU
    National networks: MetaboHub, RFMF, Lipidomystes, INSERM Microbiota Consortium
    International networks: ELM, MPF, metabomeeting, european regional metabolomics networks



Marie Lhomme (IR, ICAN)

Operational manager

Dr Anatol Kontush (DR, UMR ICAN 1166)

Scientific Director

Maharajah Ponnaiah (IR, ICAN)

data scientist

Sora Lecocq (Tech, ICAN)


Scientific Committee

Prof. F. Mochel (ICM)

Dr. F. Lamari (APHP)

Dr. G. I. Boneca (Pastor)

Dr F. Fenaille (CEA)

Wilfried Le Goff (UMR ICAN 1166)


47-48 hospital bd
75013 Paris
ICAN – building E3M – 6th floor

Access conditions

  • Download the form below and return to
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  • After validation, estimate drawn up and project initiated
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Major Publications